BMS-599626 HCl
BMS-599626 (Hydrochloride)
CAS: 873837-23-1
Molecular Formula: C27H28ClFN8O3
BMS-599626 HCl - Names and Identifiers
BMS-599626 HCl - Physico-chemical Properties
| Molecular Formula | C27H28ClFN8O3 |
| Molar Mass | 567.0144232 |
| Solubility | 10 mM in DMSO |
| Storage Condition | -20℃ |
| In vitro study | BMS-599626 Hydrochloride inhibits the proliferation of tumor cells that are dependent on HER1/HER2 signaling.BMS-599626 Hydrochloride (0.03-8 μM; 1 huors) results in the inhibition of receptor autophosphorylation, as well as MAPK phosphorylation, with IC 50 s of 0.3 and 0.22 μM, respectively, in Sal2 cells which express a CD8HER2 fusion protein. BMS-599626 Hydrochloride abrogates HER1 and HER2 signaling and inhibited the proliferation of tumor cell lines that are dependent on these receptors, with IC 50 s in the range of 0.24 to 1 μM.In GEO cells, HER1 phosphorylation is stimulated by treatment with EGF and is inhibited by BMS-599626 Hydrochloride (IC 50 =0. 75 μM).There is also nearly complete inhibition of EGF-dependent MAPK (0. 8 μM) but only partial inhibition of AKT signaling.The latter likely reflects the activation of AKT by multiple upstream signals.Treatment of N87 cells with BMS-599626 Hydrochloride leads to the inhibition of HER2 (0. 38 μM), which is expressed to a high level because of gene amplification, as well as MAPK and AKT phosphorylation (0.35 μM for both). At the molecular level, in HN-5 cells the agent (BMS-599626 Hydrochloride) inhibits the expression of pEGFR, pHER2, cyclins D and E, pRb, pAkt, pMAPK, pCDK1 and 2, CDK 6, and Ku70 proteins. BMS-599626 Hydrochloride also induced accumulation of cells in the G1 cell cycle phase, inhibited cell growth, enhanced radiosensitivity, and prolonged the presence of γ-H AX foci up to 24 h after radiation. |
BMS-599626 HCl - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.764 ml | 8.818 ml | 17.636 ml |
| 5 mM | 0.353 ml | 1.764 ml | 3.527 ml |
| 10 mM | 0.176 ml | 0.882 ml | 1.764 ml |
| 5 mM | 0.035 ml | 0.176 ml | 0.353 ml |
Last Update：2024-01-02 23:10:35
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Product Name: BMS-599626 (Hydrochloride) Visit Supplier Webpage Request for quotation
CAS: 873837-23-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 873837-23-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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